FROM DISEASE MODELLING TO PERSONALISED THERAPY IN PATIENTS WITH CEP290 MUTATIONS [VERSION 1; REFEREES: 2 APPROVED]

From disease modelling to personalised therapy in patients with CEP290 mutations [version 1; referees: 2 approved]

Mutations that give rise to premature termination codons are a common cause of inherited genetic diseases.When transcripts containing these changes are generated, they are usually rapidly removed by the cell through the process of nonsense-mediated decay.Here we discuss observed changes in transcripts of the centrosomal protein CEP290 resulting Pla

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Uncertainty effect on seismic capacity assessment in the out-of-plane failure mechanisms of masonry structures by probabilistic and non-probabilistic approaches

The present paper aims to provide a contribution in the study of the seismic analysis of existing masonry structures in presence of uncertain parameters described by following both probabilistic and non-probabilistic models.By posing the attention on the local out-of-plane failure mechanisms, the non-deterministic analysis is conducted on the kinem

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Adverse affects of drugs on saliva and salivary glands

Saliva is the most valuable oral fluid is critical to the preservation and management of oral health.Saliva containing various organic and inorganic substances provides primary natural protection for teeth and soft tissues in the oral cavity assists in mastication, deglutition and digestion of food.The secretion of Playstation Extension Lead saliva

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